Helps In Managing Diabetes:
A study in Nigeria has proven that Soursop can help in managing diabetes. It can assist in maintaining a lower blood sugar level if consumed regularly.
Soursop can help the pancreases to produce new insulin-producing cells that can be used when these cells have stopped functioning.
The leaf extract can decrease the oxidative damage to the liver which is exacerbated by diabetes in people. Make sure, when you drink Soursop juice, you should not add any sweetener or sugar otherwise you will not get any benefits.
Soursop is delicious, versatile and a perfect addition to your diet with its enormous health benefits. Not only it makes you healthy from within but also nourishes your hair and skin.
You can eat the fruit or make juices and milkshakes. Also, the leaves can be dried and brewed to make some heavenly tea.
Letâs see a few recipes for this delightful fruit.
Soursop Tea Risks And Side Effects
Memorial Sloan Kettering Cancer Center advises that you don’t consume soursop or soursop leaves if you:
- Are taking blood pressure medication
- Are taking diabetes medication
- If you are having any nuclear imaging studies performed
The organization also adds that repeated use may cause liver and kidney toxicity and that side effects of soursop may include movement disorders and myeloneuropathy .
The Bottom Line: Eat Your Soursop Or Drink Your Soursop Tea
Existing knowledge based on in-depth medical and scientific research studies supports the fact that extracts of the soursop can in fact inhibit the growth of cancer cells, potentially preventing, fighting, and even curing cancer. More research is necessary to identify the exact mechanisms of how soursop extracts work, as well as clinical trials to test and verify its potential as an anti-cancer agent. However, as of today, enough studies have shown anti-cancer properties in soursop to encourage thousands of people around the world to start introducing this fruit into their diets.
As excitement over the potential cancer-fighting properties of the soursop grows, the fruit and its extracts are becoming more easily available on the market. It is now easy to order farm-grown soursop fruit online and purchase related products such as organic soursop leaves for tea. People living in tropical climates with easy access to soursop fruit have consumed the fruit and its byproducts for centuries, accepting it as a superfruit that has beneficial properties for almost the entire body. Soursop is rich in vitamins and nutrients, as well as several antioxidants not to mention the potential anti-cancer elements.
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Fractionation Of Annona Muricata L Leaf Extract
Approximately 30 g of A. muricata leaf extract was dissolved in 500 mL of water. The extract solution was poured into a separating funnel, and an n-hexane solvent was added with the same volume as the water . First, the n-hexane phase was collected and then added back to the same volume of n-hexane solvent in the water phase. A rotary evaporator was used to obtain a thick fraction from the solvent. The water phase from the fractionation with n-hexane was returned to a separating funnel, and ethyl acetate was added with the same volume . The ethyl acetate phase was collected and then added back to the same volume of ethyl acetate solvent in the water phase. A rotary evaporator was used to obtain a thick fraction from the solvent. The water phase obtained from ethyl acetate fractionation was concentrated using a rotary evaporator. All fraction yields were calculated using the formula, yield fraction = × 100.
Impact Of Graviola On Head And Neck Squamous Cell Carcinoma
Researchers from the Farooqia Dental College and Kidwai Memorial Institute of Oncology in India evaluated the cytotoxicity of Graviola/soursop in Human tongue Squamous Cell Carcinoma cells / SCC-25 cell lines. The study found significant dose-dependent inhibition of Human tongue Squamous Cell Carcinoma cell lines by Graviola.
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Side Effects On Normal Cells
Measured toxicity of the leaf extract in different concentrations. WRL-68 = normal liver cells, HaCaT = normal skin cells, MDA-MB-435S = breast cancer cells.
Conducted at a school in India, the leaf extract of soursop was tested against normal liver cells, normal skin cells and cancerous breast cells .
They said most of the observed chemo-preventive potential invariably correlated with the amount of total phenolics present in the extract but do keep in mind correlation does not mean causation.
As far as how the graviola safety measured up in the experiments, this chart shows how while it showed toxicity against the carcinoma cells, look at the similar effects it had on healthy liver and skin cells.
the extract was moderately cytotoxic to normal cells when compared with those obtained for cancerous cells
So it was still moderately toxic even to the tested healthy cells.
Links To Other Disorders
Most studied are soursop’s fatty acid derivatives called annonaceous aceteogenins. The predominant acetogenin is annonacin, which, because of its toxicity, likely would not be studied in clinical trials.
When used orally, soursop is classified as likely unsafe, said Kellman, citing two studies. Eating the fruit could lead to movement disorders similar to Parkinson’s disease, according to a case-control study in the French West Indies. In addition, a study suggests tea made for the leaves and stems of graviola is associated with neurotoxicity.
In general, some cancer patients use herbal supplements to relieve their symptoms and to treat their cancer. Herbal supplements, though, are not a substitute for mainstream cancer care. What’s more, using herbal supplements while undergoing chemotherapy could reduce the efficacy of chemotherapeutic agents due to possible herb-drug interactions.
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Dissenting Opinions About Soursop And Its Anticancer Potency
As much as the research cited in this article is based on legitimate science and research, there are some organizations that disagree with the premise that soursop has anticancer properties. There are as follows:
- There is no evidence to show that graviola works as a cure for cancer. Cancer Research UK
- as yet, there have been no large scale tests on humans and there is no credible evidence to support claims that graviola is an effective cure or treatment for cancer Hoax-Slayer.com
- The fruit from the graviola tree is a miraculous natural cancer cell killer. UNDETERMINED.-Snopes.com
Guanabanas And Paw Paws
The long, prickly fruit comes from the graviola tree, an evergreen native to Mexico, the Caribbean, and Central and South America. It’s also known as custard apple, guanabana and Brazilian paw paw. Practitioners of herbal medicine use soursop fruit and graviola tree leaves to treat stomach ailments, fever, parasitic infections, hypertension and rheumatism. It’s used as a sedative, as well.
But claims of the fruit’s anti-cancer properties have attracted the most attention. A study published in the Journal of Medicinal Chemistry in 1997 suggests that soursop compounds tested on breast cancer cells in culture were more effective than chemotherapy in destroying the cells. But, without clinical trials, there is no data to support the claim.
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Research Into Graviola As A Cancer Treatment
Websites or magazines often promote graviola. They base their claims on unsupported opinions and anecdotal evidence. There isnt reliable scientific evidence that graviola works as a cancer treatment.
In 2015 a systematic review was published. This means that a group of experts gather all the evidence about a particular subject and go through it to work out whether there is any evidence to support it. It said that several studies show positive results in using graviola. But that there needs to be more robust and systematic clinical trials to test and confirm its value in cancer treatment, and to see if it is safe. Only then can it be used as a treatment for cancer.
Guanabana And Cancer Cure: How To Prepare Tea From Guyabano Leaves
Few people know about Guanabana tree, its fruit and its leaves used as an alternative treatment for various cancers. Guanabana is a spiny fruit related to custard apple with a sour tasting pulp. The tropical fruit is addressed by various names in different parts of the world. The Caribbeans call it soursop, the Brazilians and people living in Central America call it Guanabana, and Spaniards refer the tree and the fruit as Graviola.
When young, the fruit is consumed as a vegetable dish. The pulp of ripe guanabana fruit is eaten raw or used as a fruit drink.
The fruit, leaves and bark of guanabana are used in herbal medicines since centuries however it was only in later half of twentieth century, experts began dedicated research in relationship with guanabana and cancer treatment.
This rain-forest tree has the capacity to revolutionize the treatment of cancer and thus increase the chances of survival of the cancer patients. Although many parts of this miraculous tree are used to treat various disorders, the leaves and bark of guanabana tree are used to treat cancer. Scientists have found phytochemicals and acetogenins as useful substances to fight cancer cells from guanabana.
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Impact Of Graviola On Colon Cancer
A study done by the researchers from the Universitas Indonesia in Jakarta, Indonesia evaluated the apoptosis-inducing effect of graviola/soursop leaf extract on the colorectal cancer cell line COLO-205 through the activities of caspase-3 which is a marker of cell apoptosis. The study suggested that Annona muricata leaf extract had anticancer properties by enhancing caspase-3 activity.
Possible Side Effects Of Graviola/soursop
Random and long-term use of Graviola/Soursop supplements may be associated with various side-effects including:
- Nerve cell damage, nerve changes and neurological problems like Parkinsons disease, and other conditions with hallucinations
- liver and kidney toxicity
- movement disorders
Graviola may also lower blood sugar levels and blood pressure. Hence, consult with your doctor before taking Graviola/Soursop along with other medications for these conditions. Also avoid taking graviola supplements if you:
- are pregnant
- have liver or kidney disease
- take medications for diabetes
- have low blood pressure
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What Could Soursop Mean For The Future Of Cancer Medicine
Dozens of medical research studies on soursop-derived compounds since at least the early 1970s have found evidence of the soursops ability to stop and fight cancer cells, thanks to the active ingredient annonaceous acetogenins. Studies on mice and humans have come to the same conclusion again and again annonaceous acetogenins can and will have inhibited cancer cell growth and lead to programmed cancer cell death. Despite the large number of laboratory studies with cancer-fighting results, there are still doubts about the soursops capabilities in the industry.
Can Guyabano Cure Cancer
I remember receiving an e-mail that soursop or guyabano is tens of thousands more potent than chemotherapy. Having just lost a friend this year due to cancer, I looked at the title and trashed the copy dismissing it as another one of those incredulous claims.
Then I met a biochemist from a reputable university who claims three personal encounters with the efficacy of the plant. She excitedly recounted to me in between rounds of freshly roasted Bataan coffee from her plantation that the latest case involved the local barangay captain who was diagnosed with cancer. My husband knows him. His family was advised to prepare for the worse as he was thought to have only six months to live. Waiting for the prospect of a costly surgery, the patient got depressed and was resigned that he will not survive this. Gina boosted his morale and gave the friendly advice of taking tea from the soursop bark and leaves.
Apparently, the barangay captain did just that. He drank the soursop tea as his water for three months. He felt better and better and when he had another scan not a single tumor was seen. He was declared cancer-free!
That, of course, became a celebrated miracle in this sleepy Bataan town. I am sure they are planting guyabano obsessively as more and more harvest the fruits, leaves and bark.
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Ways Soursop Tea Can Benefit Your Health
Freshly Rooted TribeContents
Walk into any health food store and youll immediately see the vast variety of herbal products available especially teas. Everyones always looking for the latest drink that will keep their bodies happy and healthy.
Speaking of healthy drinks, weve got another contender to add to your list:soursoptea.
It might not be as common as green or chamomile teas, but it does have some amazing health benefits. We want to share some of the research behind this tea and its medicinal properties. Keep reading to learn how drinkingsoursoptea can help your body, as well as how this tea came into popular culture.
Side Effects Of Using Soursop To Cure Cancer
Every treatment have side effects, Soursop is not exeptional. Although it has way less side effects that those chemical treatments that financially drains you. In 2002, there is a study which shown the association of Parkinsons disease to an exessive consumption of Soursop in West India.
The study was actually not conducted on humans, the researchers use neutron. But still, we have to be cautious of it. Make sure that you dont consume too much Soursop. The recommended intake of Soursop fruit or supplement is less than 500mg per day. So, make sure you remember it, and always consult with your doctor. And always be cautious of Symptoms of Colon Cancer in Men and Women.
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Impact Of Graviola On Breast Cancer
In an experimental study done by the researchers from the Universiti Putra Malaysia, they evlauted the anti-proliferative and anti-cancer effects of Annona muricata crude extract / graviola extract / soursop extract on breast cancer cell lines. Some of the studies were done only with its most potent leaf aqueous extract called B1 AMCE. The study found that Annona muricata crude extract samples exhibited different levels of cytotoxicity towards breast cancer cell lines. The most potent selected B1 AMCE reduced the breast tumors size and weight, showed anti-metastatic features , and induced apoptosis of the 4 T1 cells in vitro and in vivo. Additionally, the study found that graviola decreased the levels of nitric oxide in tumor and increased the white blood cell, T-cell, and natural killer cell population and suggested B1 AMCE as a promising candidate for breast cancer treatment.
Soursop Helps Fight Bacteria And May Prevent Disease
Soursop contains anti-bacterial properties that may help prevent disease. In one study, researchers note that soursop was able to kill multiple kinds of bacterias including gingivitis, tooth decay, and yeast infections.
In yet another study, “extracts of soursop showed an antibacterial effect against S. aureus and V. cholera,” a bacteria found in contaminated water and food which can lead to dehydration and death by an infection in the intestines. Cholera is a prominent bacteria found in Africa, Southeast Asia, and Haiti.
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Extract Of Annona Muricata L Leaves
Annona muricata L. leaves were dried under a net in sunlight. The extract was prepared via the maceration method where up to 3.1 kg of A. muricata leaves was extracted with up to 50 L of 70% ethanol. After 24 h, the liquid extract was collected. The solvent was then evaporated with a rotary evaporator at 45°C. The extract was concentrated using a freeze dryer at a temperature of 80°C to obtain a thick total extract. The yield of extract was calculated as × 100.
Ethyl Acetate Fraction Had The Most Effective Inhibitory Activity Of Mcf7 Cells Proliferation
We assessed the inhibitory activity of samples for 24 h against MCF7 and CV1 cells. The best IC50 values for the A. muricata leaf extract obtained against MCF7 breast cancer cells were from 5.3 µg/mL ethanol extract, whereas ethyl acetate, n-hexane, and water fractions produced effective IC50 values at 2.86, 3.08, and 48.31 µg/mL, respectively. The ethyl acetate fraction against MCF7 cells had the most effective inhibitory ability with an IC50 value of 2.86 µg/mL and did not have any cell inhibitory effect on CV1 cells . The graph of A. muricata leaves extract and fractions proliferation assay results is shown in Figure 1. A. muricata leaves extract and ethyl acetate fractions also assessed on A549 and HeLa cell proliferation ability after treatment for 48 h .
Table 2 IC50 Values 24 h of A. muricata Leaves Extract, and Its Fractions ie, Ethyl Acetate, n-Hexane, and Water Fraction on MCF7 and CV1 Cells
Figure 1A. muricata L. extract and fractions, ie, ethyl acetate, n-hexane and water, effect on MCF7 cells proliferation. MCF-7 cells treated in various concentrations of A. muricata L. for 24 h. Data are presented as mean ± standard deviation.
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Extraction And Fractionation Of A Muricata Leaves And Acetogenin Detection
The yield of the extract obtained from approximately 3.1 kg of A. muricata leaves was 17.01% at 527.39 g. We used 155 g of A. muricata leaf extract for fractionation and obtained fraction yields of 0.5% , 19.01% , and 85% for the n-hexane, ethyl acetate, and water fractions, respectively. A TLC test pattern of the A. muricata extract using n-hexane:ethyl acetate produced five spots. The spot with a Rf value = 0.4 indicated the presence of an acetogenin compound. The evidence for the presence of acetogenin was further strengthened by TLC results that showed spots from the ethyl acetate fraction of A. muricata leaves at a Rf value = 0.4 , which had a pink-red color with AlCl3 solution and a pink color with Ehrlich solution .